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Sulfamethoxazole/Trimethprim (SMZ-TMP)

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Sulfamethoxazole/Trimethprim, also known as SMZ/TMP, is a prescription medication that is used to treat a number of infections that are common in horses. A member of the sulfonamide class of drugs, the medication works by killing certain strains of bacteria that are the cause of infections using two different drugs in combination. The antibiotic is often used for urinary tract infections as well as for infections of the respiratory system, stomach and intestines, ears and skin caused by bacteria. In some cases, veterinarians may prescribe the drug in order to prevent the return of certain types of infections, such as vaginitis and metritis infections of a horse’s reproductive tract. This medication is available only with a veterinarian’s prescription and is FDA-approved for equine use only.

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Dosage: 960mg tablets

Sulfamethoxazole / Trimethoprim is a combination of antibiotics traditionally used in the treatment of conditions like infections in the urinary tract, skin, and middle ear, as well as diarrhea, bronchitis, and bacillary dysentery, among others. It is also used for the treatment of a very severe kind of pneumonia, which is known as Pneumocystis Carinii Pneumonia or PCP, which is commonly experienced by people who have AIDS. Although it is commonly administered on individuals who are immune deficient, it is also popularly being used for horses.

If used for horses, which can also be used in treatment of bacterial infections for dogs, cats, and other animals, some of the most popular brands of Sulfamethoxazole / Trimethoprim in the market include the following: Equisul-SDT, Uniprim Powder, Ticoprim Powder, and Tribessen 400 Oral Paste. It is a combination drug that is believed to be more effective compared to using the two antibiotics in their separate forms. When used alone, they cannot kill bacteria. On the other hand, when they are use together in the form of Sulfamethoxazole / Trimethoprim, it can be bactericidal.

Some of the conditions that often warrant its use amongst horses commonly include one of the following: respiratory infections, acute strangles, wound infections, uterine infections, abscess, metritis, vaginitis, and acute urogenital infections. They can be taken orally, either as a powder or as a paste. Alternatively, they can also be administered in the form of an injection by someone who has an experience in executing intravenous or intramuscular injections. They are normally given on to twice a day for a period of 5 to 10 days.

Especially when the instructions of the veterinarian are not followed in having Sulfamethoxazole / Trimethoprim administered in horses, there are various side effects that could emanate. One of the most popular is diarrhea. More so, it is also possible to develop hypersensitivity. It is also not uncommon for crystals to be found in the urine of the horse. This should never be a problem as long as you make sure that the horses are well-hydrated during the process of taking this antibiotic. Pale gums and tiredness can also be apparent, which are indicative of anemia. This can also possibly lead into bleeding. Horses can also develop allergic reactions, which can be in the form of swelling, shock, and seizure, among others. To avoid any of the common side effects, make sure to follow only the instructions of the veterinarian and to avoid having it administered in horses with hypersensitivity, liver disease, and blood disease.

Sulfamethoxazole / Trimethoprim can lead into toxicity when the wrong doses are administered. Common sigs of overdose include diarrhea, depression, facial swelling, and paleness. Make sure to get in touch with a veterinarian as soon as possible once these signs start to show.


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