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Simplicef is an antibiotic medication that is used for treating certain types of infections caused by bacteria, fungus and protozoa in dogs of all ages and breeds. The drug is FDA approved but is only available for purchase with a prescription from a vet. One of the main benefits of this antibiotic is that is very simple for owners to administer. The cephalosporin antibiotic drug typically only needs to be given once per day and it can be taken with or without food, making dosing guidelines very flexible. For easy swallowing, the tablets have a film coating on their exteriors. Most often, Simplicef is prescribed to clear up infections in skin wounds and to cure abscesses in dogs, but it may also be used to treat urinary tract infections and other illnesses.

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Simplicef is an antibiotic cephalosporin tablet that’s orally administered to dogs and in some cases; cats are prescribed these tablets too. This FDA-approved antibiotic is for use or ordered by a veterinarian only as per the US Federal Law. Simplicef is used as an effective treatment for various skin infections in canines, and it is conveniently administered on large dogs.

Simplicef is a cefpodoximeproxetil tablet that’s available in doses of 100 mg and 200 mg. This simple medication administered once a day only can be taken with or without food. However, it is recommended to administer it with food to increase body absorption. Prescription must be made by a veterinarian. The usual dose administered by mouth is 2.3 to 4.5 mg per pound for2 to 3 days or 5 to 7 days. If this should be used for an extended period, it must not exceed 28 days.

Simplicef can treat the following infections and more:

  1. Ear infections
  2. Urinary tract infection
  3. Skin diseases
  4. Other bacterial infections

With Simplicef prescription, most dogs would respond well to the treatment. In three days, infection should start healing. If not, you pet may have more multiple bacterial infections, or an infection that’s caused by something else other than bacteria. Your dog may also have other diseases that prevent the body from fighting off infection, or your pet is stresses. In some cases, a different antibiotic may be needed because different bacteria other than those that can be treated by Simplicef exist. If your pet continues to be unresponsive to treatment, you need to check back with your veterinarian so further tests may be done, and a different antibiotic will be prescribed.

Strictly follow the prescription of your veterinarian. Even if your pet seems well and relieved of any symptoms of an infection, do not discontinue using Simplicef unless instructed by your vet to do otherwise. It is highly important to monitor how your pet reacts to the medication to avoid further diseases.

Precautions and Side Effects

Dogs that are allergic to cefpodoxime, other cephalosporins and penicillins should not be given Simplicef. Make sure that your veterinarian is informed about anything in your dog’s history that could affect this prescription. Though most pets tolerate Simplicef well, there are some side effects that have been reported including decrease in appetite, diarrhea and vomiting. If any of these occur, stop the medication right away and call your veterinarian.

Simplicef should not be used on dogs that are nursing or pregnant. If your dog will be bred soon, it shouldn’t be used as well. Simplicef should also not be used in combination with other medications without prior approval of the veterinarian; most importantly it shouldn’t be administered with antacids like Maalox or Tagamet and other stomach acid-reducers.


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